Kidney Retransplantation after Graft Failure: Variables Influencing Long-Term Survival
Table 1
Patient characteristics and surgical details.
Patient’s characteristics
1st transplantation
2nd transplantation
value
n
1,376
192
Age, median (years, range)
48.4 (2–81)
46.2 (13–73)
0.3
Gender (male/female (%))
63.2/36.8
62.5/37.5
0.8
Time on dialysis, median (years, range) 1–3 years ≥3 years CAPD
1.7 (0–15.5) 436 (32.7%) 408 (30.6%) 218 (15.8%)
2.5 (0–17.7) 55 (29.4%) 85 (45.5%) 43 (22.4%)
<0.001 0.002 <0.001 0.02
Time on the waiting list, median (days, range)
329 (0–13,951)
623 (0–4,443)
0.1
BMI (kg/cm2)
>30
138 (10.0%)
11 (5.7%)
0.06
<17
8 (0.6%)
2 (1.0%)
0.4
Underlying disease
Diabetes
219 (15.9%)
13 (6.8%)
<0.001
Hypertension
204 (14.8%)
21 (10.9%)
0.2
Glomerulopathy
238 (17.3%)
57 (29.7%)
<0.001
Cystic disease
230 (16.7%)
20 (10.4%)
0.02
Types of transplantation
Preemptive
232 (16.9%)
14 (7.3%)
0.001
Living donors
443 (32.3%)
149 (22.4%)
0.006
(i) Unrelated
239 (54%)
92 (62%)
(ii) Related
204 (46%)
57 (38%)
(1) 1st degree
94%
82%
(2) 2nd degree
6%
18%
DCD
94 (6.8%)
2 (1.0%)
0.002
Extended donors
357 (25.9%)
12 (6.3%)
<0.001
Charlson–Deyo index, median
2 (2–8)
2 (2–6)
0.6
Cold ischemia time, median (hours)
8 (1–37)
9 (1–29)
0.6
HLA mismatches
Median (range)
3 (0–6)
4 (0–6)
<0.001
0
92 (6.7%)
2 (1.0%)
0.002
1–2
347 (25.3%)
35 (18.2%)
0.03
3–5
831 (60.5%)
136 (70.8%)
0.005
≥6
104 (7.6%)
19 (9.9%)
0.05
DSA
Any patient with DSA
638
101
Median number (range) of DSA
0 (0–5)
0 (0–6)
<0.001
Patients with:
No DSA
541 (84.8%)
54 (53.5%)
<0.001
1 DSA
68 (10.7%)
29 (28.7%)
<0.001
2 DSA
20 (3.1%)
12 (11.9%)
<0.001
≥3 DSA
9 (1.4%)
6 (5.9%)
0.01
DSA cumulative MFI
Median (range)
0 (0–12,949)
0 (0–25,741)
<0.001
Mean ± SD
361+/−50.6
2,087+/−432
0
541 (84.8%)
54 (53.5%)
<0.001
1–1,000
38 (6.0%)
12 (11.9%)
0.03
1,001–2,000
25 (3.9%)
11 (10.9%)
0.002
>2,000
34 (5.3%)
24 (23.8%)
<0.001
Clavien–Dindo index, major
IIIb
8.8%
8.9%
0.9
IVa
3.1%
2.6%
0.2
IVb
0.9%
0%
0.4
V
0.7%
1.0%
0.6
Note. BMI, body mass index (kg/m2); CAPD, continuous ambulatory peritoneal dialysis; DCD, donor after circulatory death; HLA, human leukocyte antigen; DSA, donor-specific antibody; MFI, mean fluorescence densitometry; SD, standard deviation.
