Journal of Transplantation

Islet Transplantation & β-Cell Replacement Therapies for Diabetes


Publishing date
01 Nov 2011
Status
Published
Submission deadline
01 May 2011

1Diabetes Research Institute, University of Miami, Miami, FL 33136, USA

2Department of Surgery, University Hospitals of Geneva, 1211 Geneva 14, Switzerland

3Department of Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden

4Department of Surgery, University of California, San Francisco, CA 94143, USA


Islet Transplantation & β-Cell Replacement Therapies for Diabetes

Description

Restoration of physiologic metabolic control is the ultimate therapeutic goal for patients with diabetes, which is difficult to achieve by means of medical therapy. Transplantation of islet of Langerhans represents a viable therapeutic option for patients with insulin-dependent diabetes. It is currently offered to patients with a brittle form of diabetes and hypoglycemia unawareness. Current limitations of islet transplantation include scarcity of deceased donor pancreata, partially effective islet isolation and purification protocols, need for life-long systemic immunosuppression, inadequate implantation sites, lack of predictive tests, and noninvasive graft monitoring protocols, amongst others. Great progress has been recorded in different research areas aimed at overcoming current limitations of islet cell transplantation in the fields of stem cells, xenotransplantation, in the definition of novel immunosuppressive regimens, immune tolerance and immunoisolation protocols, alternative sites for islet implantation, immune monitoring, and noninvasive imaging techniques.

We invite investigators to contribute original research articles as well as review articles on islet cell transplantation (e.g., clinical, preclinical, translational, and basic research) that will stimulate the continuing efforts toward successful beta-cell replacement therapies for diabetes mellitus. Potential topics include, but are not limited to:

  • Clinical islet transplantation (evaluation and measuring outcomes, new agents, regulatory aspects, and effects of the transplant on diabetes complications)
  • Cell processing (pancreas utilization, organ preservation, and predictive tests of islet potency)
  • Islet transplant immunobiology (inflammation, autoimmunity, and rejection)
  • Immune modulation and tolerance induction
  • Impact of immunosuppressive drugs on beta cells
  • Monitoring (immune, metabolic, and noninvasive imaging)
  • Alternative sources of transplantable islet cells (stem cells and xenotransplantation)
  • Tissue engineering and alternative implantation sites for islet cells (devices, encapsulation, etc.)

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/jtran/guidelines.html. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 157840
  • - Editorial

Islet Transplantation & β-Cell Replacement Therapies for Diabetes

Thierry Berney | Olle Korsgren | ... | Antonello Pileggi
  • Special Issue
  • - Volume 2011
  • - Article ID 141898
  • - Review Article

Induction of Protective Genes Leads to Islet Survival and Function

Hongjun Wang | Christiane Ferran | ... | Leo E. Otterbein
  • Special Issue
  • - Volume 2011
  • - Article ID 352043
  • - Review Article

Striated Muscle as Implantation Site for Transplanted Pancreatic Islets

Daniel Espes | Olof Eriksson | ... | Per-Ola Carlsson
  • Special Issue
  • - Volume 2011
  • - Article ID 637692
  • - Review Article

Current Status of Immunomodulatory and Cellular Therapies in Preclinical and Clinical Islet Transplantation

Preeti Chhabra | Kenneth L. Brayman
  • Special Issue
  • - Volume 2011
  • - Article ID 202915
  • - Review Article

Molecular Imaging: A Promising Tool to Monitor Islet Transplantation

Ping Wang | Zdravka Medarova | Anna Moore
  • Special Issue
  • - Volume 2011
  • - Article ID 247959
  • - Review Article

Evolution of 𝜷 -Cell Replacement Therapy in Diabetes Mellitus: Islet Cell Transplantation

Cyrus Jahansouz | Cameron Jahansouz | ... | Kenneth L. Brayman
  • Special Issue
  • - Volume 2011
  • - Article ID 418902
  • - Review Article

B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies

Xiaojie Wang | Jianqiang Hao | ... | Garth L. Warnock
  • Special Issue
  • - Volume 2011
  • - Article ID 892453
  • - Review Article

β-Cell Generation: Can Rodent Studies Be Translated to Humans?

Françoise Carlotti | Arnaud Zaldumbide | ... | Eelco J. de Koning
  • Special Issue
  • - Volume 2011
  • - Article ID 261352
  • - Review Article

Engraftment of Insulin-Producing Cells from Porcine Islets in Non-Immune-Suppressed Rats or Nonhuman Primates Transplanted Previously with Embryonic Pig Pancreas

Marc R. Hammerman
  • Special Issue
  • - Volume 2011
  • - Article ID 783168
  • - Review Article

Pancreas Procurement and Preservation for Islet Transplantation: Personal Considerations

Hirofumi Noguchi
Journal of Transplantation
 Journal metrics
Acceptance rate13%
Submission to final decision41 days
Acceptance to publication36 days
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