Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes

<table>Dynamics of the level of virus-neutralizing antibodies during intracutaneous immunization of BALB/c mice with the polyvalent DNA vaccine pcDNA-A30L, pcDNA-F8L, pcDNA-M1R, pcDNA-A36R, and pcDNA-B7R (pcDNA-Σ5); intraperitoneally with the polyvalent DNA vaccine pBKRSV-A30L, pBKRSV-F8L, pBKRSV-M1R, pBKRSV-A36R, and pBKRSV-B7R (pBKRSV-Σ5); or intraperitoneally with VACV detected by VACV neutralization in Vero cell culture. Mean values of the neutralization (%) for serum dilution of 1 : 100 ± standard deviations are shown. Numbers 1, 2, and 3 indicates the number of immunizations. </table>

Journal of Vaccines

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Figure 4: Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes 