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Journal of Veterinary Medicine
Volume 2014 (2014), Article ID 758581, 4 pages
http://dx.doi.org/10.1155/2014/758581
Research Article

Biochemical Effects of Xylazine, Propofol, and Ketamine in West African Dwarf Goats

1Department of Veterinary Surgery and Theriogenology, College of Veterinary Medicine, Michael Okpara University of Agriculture, Umudike, PMB 7267 Umuahia, Abia State, Nigeria
2Department of Veterinary Surgery and Radiology, Faculty of Veterinary Medicine, University of Nigeria, Nsukka, Nigeria

Received 27 June 2014; Revised 31 August 2014; Accepted 1 September 2014; Published 14 September 2014

Academic Editor: Nora Mestorino

Copyright © 2014 Ukwueze Celestine Okwudili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Anaesthesia was induced in West African Dwarf (WAD) goats using different combinations of propofol (P), xylazine (X), and ketamine (K), and the biochemical effect of the drugs determined. Twenty male (WAD) goats were randomly assigned to five treatment groups viz. Control (C) (2.5 mL IV normal saline); group K + X (5 mg/kg IV ketamine + 0.05 mg/kg IV xylazine), group P + X (5 mg/kg IV propofol + 0.05 mg/kg IV xylazine), group P + K (propofol 5 mg/kg IV + ketamine 5 mg/kg IV), and group P + K + X (propofol 2.5 mg/kg IV + ketamine 2.5 mg/kg IV + xylazine 0.05 mg/kg IV), respectively. There was increase () in blood glucose in K + X, P + X and P + K + X. The serum cortisol level increased () in all groups except in P + X. ALT value increased () in K + X, P + K, and P + K + X. BUN increased () in K + X but decreased () in P + K + X. There was no significant variation () in serum creatinine. These biochemical changes were transient. P + K + X would be the best drug combinations considering the biochemical parameter measured. However, data on blood glucose, ALT, BUN, and cortisol levels in an anaesthsized goat should be interpreted with caution in order to avoid erroneous interpretation in these animals.