Research Article
Suspected Lonely Mouse Syndrome as a Cage Effect in a Drug Safety Study
Table 4
Frequency and percentage distributions of signs of stress increase in drug-free (control) animals over a 5-day time period.
| | Ocular score | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
| | NOA: number (%) | 26 (81.3) | 55 (85.9) | 45 (80.4) | 38 (79.2) | 22 (55.0) | | Eyes closed: number (%) | 6 (18.7) | 9 (14.1) | 11 (19.6) | 9 (18.7) | 18 (45.0) | | Crusty secretions: number (%) | 0 (0.0) | 0 (0.0) | (0.0) | 1 (2.1) | 0 (0.0) |
| | Motor score | Day 1 | Day 2 | Day 3 | Day 4 | Day 5 |
| | NOA: number (%) | 17 (53.2) | 46 (71.9) | 35 (62.5) | 31 (64.6) | 19 (47.5) | | Rapid, darting: number (%) | 11 (34.4) | 9 (14.1) | 11 (19.6) | 10 (20.8) | 8 (20.0) | | Hunched, lethargic: number (%) | 3 (9.4) | 1 (1.6) | 2 (3.6) | 0 (0.0) | 0 (0.0) | | Hunched, motionless: number (%) | 1 (3.1) | 8 (12.5) | 8 (14.3) | 7 (14.6) | 13 (32.5) |
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