Lung Cancer International / 2015 / Article / Tab 4

Research Article

Usefulness of Ki-67, Mitoses, and Tumor Size for Predicting Metastasis in Carcinoid Tumors of the Lung: A Study of 48 Cases at a Tertiary Care Centre in Canada

Table 4

A summary of select reported Ki-67 labeling indices in lung carcinoid tumors.

StudiesNumber of cases% of Ki-67 positive cells, mean (range) Counting method

Costes et al. 1995 [12]470.45 (0–3.04)2.43 (0–6.05)CIAM
Arbiser et al. 2001 [14]1019MCM
Igarashi et al. 2004 [16]181.3 (0.3–2.3)8.6 (0.2–17)MCM
Pelosi et al. 2005 [15]70.5 (0-1)7.2 (1–17)NS
Walts et al. 2012 [19]1013.7 18.8CIAM
Zahel et al. 2012 [21]2001.8 3.7MCM
Rindi et al. 2014 [20]197<4 4–<25 MCM, AACAM, and CAMM
Present case48 0.72 0.95MCM and CIAM

CIAM indicates computer image analysis method; MCM: manual conventional method; NS: not specified; AACAM: Aperio automated computer assisted method; CAMM: computer assisted manual method; TC: typical carcinoid; AC: atypical carcinoid.

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