Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer

Table 1

Proteins of the classical renin-angiotensin system (RAS) and proteins with RAS-related functions.

Name	Gene name	E.C. number	Function for RAS
Angiotensinogen	AGT	—	Precursor of Ang peptides
Renin	REN	3.4.23.15	Angiotensinogen to Ang I
Angiotensin-converting enzyme	ACE	3.4.15.1	Ang I to Ang II
Prorenin receptor	ATP6AP2	—	Activates prorenin, receptor for renin and prorenin
Chymase	CMA1	3.4.21.29	Ang I to Ang II
Neprilysin	MME	3.4.24.11	Ang I to Ang 1–7, Ang II to Ang 1–4 and 5–8
Prolylendopeptidase	PREP	3.4.21.26	Ang I to Ang 1–7, Ang II to Ang 1–7
Aminopeptidase A	ENPEP	3.4.11.7	Ang II to Ang III
Aminopeptidase N	ANPEP	3.4.11.2	Ang III to Ang IV
Angiotensin-converting enzyme 2	ACE2		Ang 1 to Ang 1–9, Ang II to Ang 1–7
Prolylcarboxypeptidase	PRCP	3.4.16.2	Ang II to Ang 1–7
AT1 Ang II receptor subtype	AGTR1	—	Ang II receptor subtype vasoconstriction, thirst
AT2 Ang II receptor subtype	AGTR2	—	Ang II receptor subtype generally opposes AT1 effects
MAS	MAS1	—	Ang 1–7 receptor
Insulin-regulated aminopeptidase		3.4.11.3	Ang IV receptor (AT4)