Lung Cancer International / 2017 / Article / Tab 2

Research Article

Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer

Table 2

Significance levels of differences in RAS and RAS-related protein gene expression in lung tumor and normal lung tissue based upon log2 values.

GENEProteinChange in expression in lung tumorSignificance level (uncorrected for multiple comparisons)Significance level (corrected for multiple comparisons)

AGTAngiotensinogen
RENRenin=NS NS
ACEAngiotensin-converting enzyme
AGTR1AT1 Ang II receptor subtype
AGTR2AT2 Ang II receptor subtype
ATP6AP2Prorenin receptorNS
CMA1Chymase=NS NS
LNPEPAng IV receptor, insulin-regulated aminopeptidase=NS NS
ENPEPAminopeptidase A
ANPEPAminopeptidase NNS ()
ACE2Angiotensin-converting enzyme-2NS
MMENeprilysin
PRCPProlylcarboxypeptidase
PREPProlylendopeptidase=NS NS
MAS1Mas, Ang 1–7 receptor=NS NS

Unpaired test with Welch’s correction; Sidak’s correction: (1 − (1 − .05)1/15) or (1 − (1 − .01)1/15) or (1 − (1 − .001)1/15; NS is nonsignificant.