Alterations in Gene Expression of Components of the Renin-Angiotensin System and Its Related Enzymes in Lung Cancer

Table 2

Significance levels of differences in RAS and RAS-related protein gene expression in lung tumor and normal lung tissue based upon log2 values.

GENE	Protein	Change in expression in lung tumor	Significance level (uncorrected for multiple comparisons)	Significance level (corrected for multiple comparisons)
AGT	Angiotensinogen	↑
REN	Renin	=	NS	NS
ACE	Angiotensin-converting enzyme	↓
AGTR1	AT1 Ang II receptor subtype	↓
AGTR2	AT2 Ang II receptor subtype	↓
ATP6AP2	Prorenin receptor	↑		NS
CMA1	Chymase	=	NS	NS
LNPEP	Ang IV receptor, insulin-regulated aminopeptidase	=	NS	NS
ENPEP	Aminopeptidase A	↓
ANPEP	Aminopeptidase N	↓		NS ()
ACE2	Angiotensin-converting enzyme-2	↑		NS
MME	Neprilysin	↓
PRCP	Prolylcarboxypeptidase	↓
PREP	Prolylendopeptidase	=	NS	NS
MAS1	Mas, Ang 1–7 receptor	=	NS	NS

Unpaired test with Welch’s correction; Sidak’s correction: (1 − (1 − .05)^1/15) or (1 − (1 − .01)^1/15) or (1 − (1 − .001)^1/15; NS is nonsignificant.