Table of Contents
Leukemia Research and Treatment
Volume 2011, Article ID 329572, 7 pages
Review Article

Understanding and Targeting the Wnt/β-Catenin Signaling Pathway in Chronic Leukemia

Department of Internal Medicine III (Hematology and Oncology), Center for Integrated Oncology (CIO), University of Bonn, Sigmund-Freud Straβe 25, 53127 Bonn, Germany

Received 30 August 2011; Accepted 14 October 2011

Academic Editor: Spiro Konstantinov

Copyright © 2011 S. Thanendrarajan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


It has been revealed that the Wnt/β-catenin signaling pathway plays an important role in the development of solid tumors and hematological malignancies, particularly in B-cell neoplasia and leukemia. In the last decade there have been made experimental approaches targeting the Wnt pathway in chronic leukemia. In this paper we provide an overview about the current state of knowledge regarding the Wnt/β-catenin signaling pathway in chronic leukemia with special focus on therapeutic options and strategies.