PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells
Figure 11
Reduced PKCδ and p-eIF2α protein expression is associated with relapses in AM patients. PKCδ and p-eIF2α protein expression was assessed by RPPA in 47 paired samples from newly diagnosed and relapsed AML patients to determine if the protein level changes when the disease status changes. The comparison of PKCδ and p-eIF2α protein expression ((a) and (c)) and distributions ((b) and (d)) of the protein levels between pairs (newly diagnosed and relapsed) were plotted. Data suggest that there is a significant association between the reduced levels of PKCδ () and p-eIF2α () and relapses in AMP patients.
