Isochromosome 17q in Chronic Lymphocytic Leukemia

Figure 1

(a) Isochromosome 17q was detected initially by iFISH in this case; representative examples for heterozygote deletions of TP53 and #17 subtelomeric region 17p (subtel. 17pter) besides three signals for UNC13D and subtel. 17qter. Only 2 signals for centromere of chromosome 17 (D17Z1) and ATM gene on chromosome 11 were detected. (b) aCGH showed deletion of short arm and gain of long arm of chromosome 17 in case 3.

(a)

(b)