Leukemia Research and Treatment

HTLV-1 Infection and Its Associated Diseases


Publishing date
01 Feb 2012
Status
Published
Submission deadline
01 Aug 2011

Lead Editor

1Department of Immunology, Graduate School and Faculty of Medicine, University of the Ryukyus, Okinawa 903-0215, Japan

2Department of Microbiology and Immunology, Drexel Institute for Biotechnology and Virology Research, Drexel University College of Medicine, Doylestown, PA 18902, USA

3Department of Molecular Medicine and Hematology, Molecular Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan

4Department of Immunology, Faculty of Medicine, Imperial College, London W2 1PG, UK


HTLV-1 Infection and Its Associated Diseases

Description

It has been more than 30 years since human T-cell leukemia virus type 1 (HTLV-1) was discovered as the first human retrovirus associated with a human cancer called adult T-cell leukemia/lymphoma (ATLL). Interestingly, HTLV-1 also causes a chronic inflammatory neurologic disorder called HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-1 is now estimated to infect up to 10 million people worldwide: endemic areas include southwestern Japan, the Caribbean basin, Central and South America, localized areas of Iran, Melanesia, and equatorial regions of Africa. Although only approximately 2%–3% develop ATLL and another 0.25%–3.8% develop HAM/TSP, both ATLL and HAM/TSP are still highly intractable to conventional therapeutics. Therefore, further research to enhance our understanding of the pathogenesis and treatment of HTLV-1 associated diseases is of crucial importance. A topic of intense investigation for HTLV-1-mediated leukemogenesis has been focused on the HTLV-1 encoded viral oncoprotein Tax, which activates many cellular target genes through binding to groups of transcription factors and coactivators and is necessary and sufficient for cellular transformation. However, recent reports indicate that another regulatory protein, HTLV-1 basic leucine zipper factor (HBZ), which is encoded on the antisense viral transcript and inhibits Tax-mediated viral gene expression, has a critical role in the development of ATL and HAM/TSP. Important progress has also been made in the treatment of ATL, such as combination therapy with zidovudine and interferon-alpha, immunotherapy with anti-IL-2 receptor or anti-CC chemokine receptor 4 monoclonal antibodies, and allogeneic bone marrow or stem cell transplantation. Potential topics include, but are not limited to:

  • Molecular pathogenesis of ATL
  • Animal models of HTLV-1 infection
  • Clinical trials for ATL
  • Treatment for ATL
  • ATL and microRNAs
  • HAM/TSP pathogenesis
  • Host immune response against HTLV-1 infection

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/lrt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 123637
  • - Editorial

HTLV-1 Infection and Its Associated Diseases

Mineki Saito | Pooja Jain | ... | Charles R. M. Bangham
  • Special Issue
  • - Volume 2012
  • - Article ID 932175
  • - Review Article

Clinical Trials of Adult T-Cell Leukaemia/Lymphoma Treatment

Ambroise Marçais | Felipe Suarez | ... | Olivier Hermine
  • Special Issue
  • - Volume 2012
  • - Article ID 984754
  • - Review Article

Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective

Nishat Aliya | Saifur Rahman | ... | Pooja Jain
  • Special Issue
  • - Volume 2012
  • - Article ID 259045
  • - Review Article

Immunopathogenesis of Human T-Cell Leukemia Virus Type-1-Associated Myelopathy/Tropical Spastic Paraparesis: Recent Perspectives

Mineki Saito | Charles R. M. Bangham
  • Special Issue
  • - Volume 2012
  • - Article ID 101754
  • - Review Article

Clinical Trials and Treatment of ATL

Kunihiro Tsukasaki | Kensei Tobinai
  • Special Issue
  • - Volume 2012
  • - Article ID 876153
  • - Review Article

Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2

Francesca Rende | Ilaria Cavallari | ... | Vincenzo Ciminale
  • Special Issue
  • - Volume 2012
  • - Article ID 128617
  • - Review Article

Pathogenesis of Metastatic Calcification and Acute Pancreatitis in Adult T-Cell Leukemia under Hypercalcemic State

Masachika Senba | Kioko Kawai | Naoki Mori
  • Special Issue
  • - Volume 2012
  • - Article ID 391953
  • - Review Article

Is There a Role for HTLV-1-Specific CTL in Adult T-Cell Leukemia/Lymphoma?

Aileen G. Rowan | Charles R. M. Bangham
  • Special Issue
  • - Volume 2012
  • - Article ID 213653
  • - Review Article

Molecular and Cellular Mechanism of Leukemogenesis of ATL: Emergent Evidence of a Significant Role for HBZ in HTLV-1-Induced Pathogenesis

Yorifumi Satou | Masao Matsuoka
  • Special Issue
  • - Volume 2012
  • - Article ID 262363
  • - Clinical Study

Diffuse Large B-Cell Lymphoma in Human T-Lymphotropic Virus Type 1 Carriers

Brady E. Beltran | Pilar Quiñones | ... | Jorge J. Castillo

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