Leukemia Research and Treatment

Differentiation and Cell Survival of Myeloid Leukemia Cells


Publishing date
03 Aug 2012
Status
Published
Submission deadline
23 Mar 2012

1School of Immunity and Infection, College of Medical and Dental Sciences, University of Birmingham, Vincent Drive, Edgbaston, Birmingham, UK

2Department of Clinical Biochemistry, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer Sheva, Israel

3Faculty of Biotechnology, University of Wroclaw, Wroclaw, Poland


Differentiation and Cell Survival of Myeloid Leukemia Cells

Description

Myeloid leukemias, acute (AML) and chronic (CML), remain diseases with many challenges for improved treatment. While AML still has dismal prognosis and the main emphasis is on the administration of cytotoxic drugs, the use of kinase inhibitors such as Imatinib has made the therapy of CML quite successful in many cases, though development of resistance to Imanitib can be a problem. Further, the success of All-Trans Retinoic Acid (ATRA) in Acute Promyelocytic Leukemia (APL), a subset of AML, offers hope as a paradigm for the successful use of differentiation-inducing agents in a wider spectrum of AMLs. These therapeutic approaches need to be extensively explored in basic studies of the altered molecular mechanisms that result from known, and from yet to be described, molecular lesions in leukemia- initiating cells (LICs). Further, the insights obtained in such studies must be validated for clinical utility using translational approaches. The main focus of this special issue will be on the new, and existing, information on the promising agents that induce differentiation of LIC, alone or in combination with co-inducers of differentiation. The Special Issue will also explore the interface between the cellular mechanisms for differentiation and cell survival mechanisms. Thus, studies, or descriptions of accumulated knowledge of the advances in the understanding of the action of cytotoxic agents, are also welcome. The Special Issue is likely to become an international forum for researchers to summarize the most recent developments and ideas in the field, with a special emphasis on experimental and clinical results obtained within the last five years. Potential topics include, but are not limited to:

  • Intracellular signaling pathways that transmit signals from currently known agents which induce differentiation and alter survival of myeloid leukemia cells, for example, retinoids, arsenic trioxide, and derivatives of vitamin D
  • microRNAs in myeloid leukemia genesis, diagnosis, and treatment
  • Role of growth factor receptors in survival of myeloid leukemia cells
  • Use of small molecule inhibitors of kinases, of DNA/histone methyltransferases and of histone deacetylases in myeloid leukemias
  • Information on the nature of LICs:— their relationship to normal hematopoietic cells, responsiveness to differentiation therapies, and development of platforms to monitor LICs
  • Clinical studies on myeloid leukemias

Articles published in this special issue will not be subject to the journal's Article Processing Charges.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/lrt/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.sage-hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2012
  • - Article ID 370375
  • - Editorial

Differentiation and Cell Survival of Myeloid Leukemia Cells

George P. Studzinski | Geoffrey Brown | ... | Ewa Marcinkowska
  • Special Issue
  • - Volume 2012
  • - Article ID 125814
  • - Review Article

Clinical Experience Using Vitamin D and Analogs in the Treatment of Myelodysplasia and Acute Myeloid Leukemia: A Review of the Literature

Jonathan S. Harrison | Alexander Bershadskiy
  • Special Issue
  • - Volume 2012
  • - Article ID 482905
  • - Research Article

PKCδ Regulates Translation Initiation through PKR and eIF2α in Response to Retinoic Acid in Acute Myeloid Leukemia Cells

Bulent Ozpolat | Ugur Akar | ... | Gabriel Lopez-Berestein
  • Special Issue
  • - Volume 2012
  • - Article ID 603830
  • - Review Article

MicroRNAs in Acute Myeloid Leukemia and Other Blood Disorders

Yao Yuan | Siddha Kasar | ... | Elizabeth Raveche
  • Special Issue
  • - Volume 2012
  • - Article ID 939021
  • - Review Article

Retinoid Differentiation Therapy for Common Types of Acute Myeloid Leukemia

Geoffrey Brown | Philip Hughes
  • Special Issue
  • - Volume 2012
  • - Article ID 401784
  • - Research Article

Cell-Type-Specific Effects of Silibinin on Vitamin D-Induced Differentiation of Acute Myeloid Leukemia Cells Are Associated with Differential Modulation of RXRα Levels

Rina Wassermann | Victoria Novik | Michael Danilenko
  • Special Issue
  • - Volume 2012
  • - Article ID 713243
  • - Review Article

Regulation of Leukemic Cell Differentiation through the Vitamin D Receptor at the Levels of Intracellular Signal Transduction, Gene Transcription, and Protein Trafficking and Stability

Elżbieta Gocek | Hanna Baurska | ... | Ewa Marcinkowska
  • Special Issue
  • - Volume 2012
  • - Article ID 671702
  • - Review Article

The Interface between BCR-ABL-Dependent and -Independent Resistance Signaling Pathways in Chronic Myeloid Leukemia

Gabriela Nestal de Moraes | Paloma Silva Souza | ... | Raquel Ciuvalschi Maia

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