Analysis of NF-B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study
Comparison of NF-B pathway protein intensities in HL patients with nonneoplastic controls. (a) Nuclear and cytoplasmic NF-B subunits from 102 HL samples (H) were compared to 10 controls (N). Significance was determined using the Wilcoxon rank-sum test. (b) Nuclear and cytoplasmic NF-B pathway subunits phospho-Rel-A (p-Rel-A), IB-, IKK, and NIK in HL samples compared to controls. (c) Intensity of nuclear NF-B subunit expression in EBV+ tumors (white bars) and EBV− tumors (grey bars) for Rel-A, Rel-B, and c-Rel. Patient average intensity scores (AIS) were placed in one of four protein intensity bins: 0–0.5 (very weak intensity), 0.5–1 (weak intensity), 1–1.5 (strong intensity), and 1.5–2 (very strong intensity).
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