Lymphoma / 2012 / Article / Fig 2

Research Article

Analysis of NF- B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study

Figure 2

Comparison of NF- B pathway protein intensities in HL patients with nonneoplastic controls. (a) Nuclear and cytoplasmic NF- B subunits from 102 HL samples (H) were compared to 10 controls (N). Significance was determined using the Wilcoxon rank-sum test. (b) Nuclear and cytoplasmic NF- B pathway subunits phospho-Rel-A (p-Rel-A), I B- , IKK , and NIK in HL samples compared to controls. (c) Intensity of nuclear NF- B subunit expression in EBV+ tumors (white bars) and EBV− tumors (grey bars) for Rel-A, Rel-B, and c-Rel. Patient average intensity scores (AIS) were placed in one of four protein intensity bins: 0–0.5 (very weak intensity), 0.5–1 (weak intensity), 1–1.5 (strong intensity), and 1.5–2 (very strong intensity).

Article of the Year Award: Outstanding research contributions of 2020, as selected by our Chief Editors. Read the winning articles.