Analysis of NF-𝜿B Pathway Proteins in Pediatric Hodgkin Lymphoma: Correlations with EBV Status and Clinical Outcome—A Children's Oncology Group Study

Table 2

(a) Univariate correlation of nuclear NF-κB pathway proteins and event free survival (EFS). (b) Correlation of NF-κB pathway proteins with EFS (multivariate analysis).

(a)

Protein	Hazard ratio	95% Confidence intervals		Significance
		LL	UL	𝑃 value^#
Phospho-Rel-A	3.3	1.2	9.0	0.023
Rel-A	1.3	0.5	3.3	0.57
Rel-B	3.8	1.2	11.6	0.02
c-rel	1.3	0.6	2.8	0.57
NF-κB1	1.1	0.5	2.9	0.79
IκB-α	1.1	0.4	3.0	0.83
IKK-α	0.9	0.3	2.9	0.88
IKK-β	1.1	0.4	3.4	0.84
IKK-γ	0.7	0.1	3.4	0.65
NIK	2.4	1.1	5.3	0.03
A20	2.6	1.1	6.4	0.03

^#Univariate Cox regression analysis. LL: lower limit; UL: upper limit.

(b)

Protein	Hazard ratio*	LL	UL	𝑃^$
Nuclear NF-κB pathway proteins
P-Rel-A	2.9	1.0	8.5	0.05
Rel-B	5.4	1.5	19.1	0.009
NIK	3.1	1.2	7.9	0.015
A20	2.8	1.1	7.2	0.03
Cytoplasmic NF-κB pathway proteins
Rel-A	3.9	1.1	14.0	0.038
Rel-B	2.5	1.0	6.2	0.05
IKK-β	5.7	2.0	16.1	0.001

*Controlling for EBV status, histology, stage, bulk disease (>6 m mass), and B symptoms.
^$Cox regression. 95% CI—LL: lower limit; UL: upper limit.