Table of Contents
Metal-Based Drugs
Volume 1, Issue 4, Pages 305-309
http://dx.doi.org/10.1155/MBD.1994.305

Synthesis, Characterization and High In Vitro Antitumour Activity of Novel Triphenyltin Carboxylates

1Free University of Brussels (V.U.B.), Pleinlaan 2, Faculty of Applied Sciences, Laboratory for General and Organic Chemistry (AOSC), Room 8G512, Brussels B-1050, Belgium
2Free University of Brussels (V.U.B.), Pleinlaan 2, High Resolution NMR Center, Brussels B-1050, Belgium
3Free University of Brussels (V.U.B.), Pleinlaan 2, Faculty of Sciences, Brussels B-1050, Belgium
4Medical Department, Pharmachemie BV, RN Haarlem NL-2003, The Netherlands
5Catholic University of Louvain, INAN, Louvain-la-Neuve B-1348, Belgium

Received 17 January 1994; Accepted 14 February 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The synthesis and spectral characterization of six novel triphenyltin compounds are described. The in vitro antitumour activity of three of these compounds against two human tumour cell lines, MCF-7, a mammary tumour, and WiDr, a colon carcinoma, was determined. All three compounds are more active than cis-platin, etoposide and doxorubicin against both tumour cell lines. They are as active as mitomycin C against WiDr, but less active against MCF-7.