The metal complexes of amine-carboxyborane including copper, chromium, zinc, calcium amd cobalt were
effective hypolipidemic agents lowering both serum cholesterol and triglyceride levels significantly in mice at
8 mg/kg/day, I.P. after 16 days. The agents reduced acetyl CoA synthetase, ATP-dependent citrate lyase, acyl
CoA cholesterol acyl transferase, sn¯-glycerol-3-phosphate acyl transferase activities of rat liver and small
intestinal mucosa after 14 days treatment. The neutral cholesterol ester hydrolase activity was elevated by the
agents in both tissues. The metal complexes altered lipid levels in the bile of rats after treatment as well as
the bile acid composition after 14 days administration, orally. The agents blocked enterohepatic absorption of
cholesterol from rat isolated intestinal loops.
