Table of Contents
Metal-Based Drugs
Volume 1, Issue 4, Pages 311-319
http://dx.doi.org/10.1155/MBD.1994.311

Contribution of H-Bonding to the Preference of Platinum Anti-Tumour Drugs for Particular Bases and Particular Cross-Links

Dipartimento Farmaco-Chimico, via E. Orabona 4, Bari I-70125, Italy

Received 11 March 1994; Accepted 29 April 1994

Copyright © 1994 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The stereochemical factors that influence the tendencies for sequence specific binding of platinum antitumour drugs to DNA are examined. The NHs of the platinum-amine moiety can form hydrogen bonds to the O6 of guanine or to a phosphate oxygen of DNA. Modelling the stereochemistry of the NH atoms can lead to compounds with a strong preference for forming one type of adduct with DNA.