Table of Contents
Metal-Based Drugs
Volume 2 (1995), Issue 2, Pages 111-122

[Ag(I)(Et2PCH2CH2PPh2)2]NO3: An Antimitochondrial Silver Complex

1School of Science, Griffith University, Queensland 4111, Nathan, Australia
2Department of Biology, University College, Gower St., London WCIE 6BT, United Kingdom
3School of Chemistry and Applied Chemistry, University of Wales, College of Cardiff, Cardiff CF1 3TB, United Kingdom
4Department of Chemistry, Birkbeck College, 29 Gordon Sq., London WC1H 0PP, United Kingdom

Received 1 December 1994; Accepted 6 January 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The silver(I) complex [Ag(eppe)2]NO3 (eppe = Et2PCH2CH2PPh2) is shown by X-ray crystallography to be tetrahedral with Ag - PEt2 and Ag - PPh2 bond lengths of 2.482 and 2.518 Å, respectively. The complex is selectively antimitochondrial and inhibits the growth of a number of yeast strains in non-fermentable media at concentrations as low as 2.5 μΜ and induces the mitochondrial mutation petite The effect is largely reversed by the presence of aspirin. The complex is shown to be stable in the cell culture media and in the presence of glutathione, but readily reacts with disulfides of oxidized glutathione and serum albumin. Surprisingly, neither [Au(eppe)2]Cl nor [Au(dppe)2]Cl (dppe = Ph2PCH2CH2PPh2) showed any mitochondrial selectivity in the same screening protocol.