Table of Contents
Metal-Based Drugs
Volume 2, Issue 1, Pages 37-42

Synthesis, Characterization and In vitro Antitumour Activity of Novel Organotin Derivatives of 1,2- and 1,7-Dicarba-Closo-dodecaboranes

1Free University of Brussels, VUB, Department of General and Organic Chemistry, Faculty of Engineering, Room 8G512, Brussels, Belgium
2Room 8G512, High Resolution NMR Centre, HNMR, Pleinlaan 2, Brussels B-1050, Belgium
3A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow 117813, Russia
4Pharmachemie BV, Medical Department, Haarlem NL-2003 RN, Netherlands Antilles
5Catholic University of Louvain, INAN, Louvain-la-Neuve, Belgium

Received 4 July 1994; Accepted 8 August 1994

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several organotin derivatives of 1,2- and 1,7-dicarba-closo-dodecaboranes were synthesized and characterized by S119n Mössbauer, H1 , C13 and S119n NMR spectroscopy. Their antitumour activities in vitro against cancerous cell lines of human origin are reported.