Table of Contents
Metal-Based Drugs
Volume 2, Issue 4, Pages 211-219

Synthesis, Structure and Antitumour Properties of a New 1,2-Propylenediaminetetraacetate-Ruthenium(III) Compound

1Dpto. de Quífmica Inorgánica, F. de Química, Universidad de Sevilla, Sevilla 41071, Spain
2Dpto. de Quífmica Inorgánica, F. de Química, Universidad de Granada, Granada 18071, Spain

Received 2 May 1995; Accepted 18 May 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A novel complex formed by ruthenium (III) and the sequestering ligand 1,2-propylenediaminetetraacetic acid (PDTA) has been synthetized and characterized. The structure of the monomeric compound, studied by X-ray diffraction , shows an almost symmetric octahedral geometry around the metal ion, with two chlorine atoms in a cis conformation. The antitumour activity against a variety of murine and human cancers is reported.