Table of Contents
Metal-Based Drugs
Volume 2, Issue 3, Pages 153-185

On the Mechanism of Action of the Antitumor Drug cis-Platin (cis-DDP) and its Second Generation Derivatives

1University of Ioannina, Department of Chemistry, Laboratory of Inorganic and General Chemistry, Ioannina 45-110, Greece
2University of Toronto, Faculty of Medicine, 1 King’s College Circle, Toronto, Ontario H4A lW3, Canada

Received 8 February 1995; Accepted 20 February 1995

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The present article attempts to summarise the elements of the mechanism of action of the antitumor drug cis¯-Platin presented the last few years. Highlights on the discovery, of the drug and the development of it’s second generation derivatives are presented, as well as the ways that cis¯-DDP reacts with biomolecules as DNA and proteins and their models e.g. nucleosides, nucleotides. Also the hydrolysis data are presented for cis¯-DDP and its’ inactive congener trans¯-DDP, as well as for the second generation drug carboplatin. Finally, usefull conclusions are given from this work, pointing out the unanswered questions about the action of cis¯-DDP as well as its differences in action, in comparison with trans¯-DDP.