Table of Contents
Metal-Based Drugs
Volume 2 (1995), Issue 4, Pages 201-210
http://dx.doi.org/10.1155/MBD.1995.201

Synthesis of 4-Amino-1-Hydroxy-Butane-1,1-Diphosphonate (AHBDP) - Stannous Complexes for the Preparation of Ahbdp-Sn(II)-Tc and its Biodistribution in Rats

1Université Paris-Nord, Laboratoire de Radiopharmacologie de la formation de Recherche Biophysique et Pharmacologie des Biosignaux (DRED), U.F.R. de Santé-Médecine-Biologie Humaine de Bobigny, France
2Universit Paris-Nord, Laboratoire de Chimie Structurale Biomoléculaire U.F.R. de Santé, Médecine, Biologie Humaine de Bobigny, URA 1430 CNRS, France

Received 1 January 1995; Accepted 13 February 2000

Copyright © 1995 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The new potential tracer of bone imaging, AHBDP-Sn(II)-TcO.3H2O was synthesized by reducing the TcO4 to TcO2+ in the presence of AHBDP and Sn(ll)’s reducing agent. We found that tin rapidly forms a stable complex with AHBDP, giving AHBDP-Sn(II).3H2O. In the excess of AHBDP-Sn(ll).3H2O, the AHBDP-Sn(II).3H2O coordinates with TcO2+ to give AHBDP-Sn(II)-TcO.3H2O which could polymerise or oligomerise to give hydrophobic species. The overall process appears as a first-order reaction (K= 0.67 ± 0.005s1). In rats, the fixation of AHBDP-Sn(II)-99m TcO. 3H2O on bone is homogeneous and the scintigraphic images have the same quality as those of 1-hydroxymethane-1,1-diphosphonate-Technetium (HMDP-99mTc). The activity in non-target organs was neglible.