Table of Contents
Metal-Based Drugs
Volume 3, Issue 3, Pages 123-130

"In Vivo" Effects of Lithium Sulphate on the Turnover of Rat Tissue Nucleotides

1Faculty of Pharmacy, University of Medicine and Pharmacy “luliu Hatieganu”, Cluj-Napoca, Romania
2Department of Biochemistry, University of Agricultural Sciences and Veterinary Medicine, str.Mănăştur 3, Cluj-Napoca 3400, Romania

Received 31 January 1996; Accepted 17 April 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The effects of lithium sulphate following acute administration to Wistar rats - in therapeutic and toxic doses - were investigated, using as markers the levels and turnover of brain, kidney and liver nucleotides. Adenine- and guanine-dependent nucleotides were assayed concomitantly, using a high- performance liquid chromatographic method. Following acute administration, lithium's effects on 3’,5’- cAMP levels were more significant at hepatic and cerebral level, in a dose-dependant manner. The effect on 3’,5’-cGMP had tissue specificity and was not dose-dependant. It might be possible that 3’,5’-cGMP is a better indicator of lithium toxicity than 3’,5’-cAMP.