Table of Contents
Metal-Based Drugs
Volume 3 (1996), Issue 1, Pages 11-14

Complexes of Zinc With Picolinic and Aspartic Acids Inactivate Free Varicella-Zoster Virions

1Laboratory of Virology, Faculty of Biology, University of Sofia, 8 Dragan Tzankov Blvd., Sofia 1421, Bulgaria
2Laboratory of Virology, Faculty of Chemistry, University of Sofia, Bulgaria
3Laboratory of Virology, Higher Medical Institute, Sofia, Bulgaria

Received 2 March 1995; Accepted 19 April 1995

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Zn(II) picolinate and aspartate, Zn(pic)2 and Zn(asp)2, have been shown to inhibit key steps of the replication of HSV-1. In the present study we describe the effect of Zn(pic)2 and Zn(asp)2 on the replication of VZV and on the infectivity of free virions. The experiments are done using BHK-21 cells, a clinical isolate of VZV and Zn-complexes in concentration of 10 μM. When Zn-complexes are present during the whole period of infection, the yield of infectious virus progeny decreases up to 98%. The infectivity of VZV is completely restored after the removal of zinc. The virucidal effect is manifested at the 2nd h of contact, when 90% of the virions are inactivated. The results show that both Zn(pic)2 and Zn(asp)2 specifically inactivate free VZV virions with no effect on viral replication.