Metal-Based Drugs

Metal-Based Drugs / 1996 / Article

Open Access

Volume 3 |Article ID 439659 |

M. B. de Oliveira, J. Miller, R. E. Banks, L. R. Kelland, C. A. McAuliffe, N. Mahmood, I. J. Rowland, "New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential", Metal-Based Drugs, vol. 3, Article ID 439659, 6 pages, 1996.

New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential

Received22 Feb 1995
Accepted07 Mar 1995


Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated.The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and H1 and C13 NMR spectra.They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines.They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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