Table of Contents
Metal-Based Drugs
Volume 3, Issue 3, Pages 117-122
http://dx.doi.org/10.1155/MBD.1996.117

New Perfluorophtalate Complexes of Platinum(II) With Chemotherapeutic Potential

1Federal University of Paraiba, Department of Chemistry/CCEN, Campus 1, João Pessoa 58059-000, PB, Brazil
2Federal University of Minas Gerais, Department of Chemistry/ICEx, Campus of Pampulha, Belo Horizonte 31270901, MG, Brazil
3Federal University of Paraiba, Laboratory of Pharmaceutical Technology, Campus 1, P.O. Box 5009, João Pessoa 58051-970, PB, Brazil
4University of Manchester Institute of Science and Technology, Department of Chemistry, P.O.Box 88, Manchester M60 1GD, United Kingdom
5CRC Centre for Cancer Therapeutics, Institute of Cancer Research, 15 Cotswold Rd, Sutton, Surrey SM2 5NG, United Kingdom
6Medical Research Council Collaborative Centre, 1-3 Burtonhole Lane, Mill Hill, London London NW7 1AD, United Kingdom
7Institute of Cancer Research, Royal Marsden Hospital, Downs Rd, Sutton, Surrey SM2 5PT, United Kingdom

Received 22 February 1995; Accepted 7 March 1995

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Two new platinum(II) complexes have been synthesized and their anti-tumour and anti-HIV activities have been evaluated.

The new complexes are: (i) cis-tetrafluorophthalate-ammine-morpholine-platinum(II) or MMF3 and (ii) cis-tetrafluorophthalate- ammine-piperidine-platinum(II) or MPF4. They were characterized by elemental analysis, IR spectra and H1 and C13 NMR spectra.

They were tested against five human ovarian carcinoma cell lines, viz., CH1, CH1cisR, A2780, A2780cisR and SKOV-3. They were less active than cis-platin and showed cross-resistance with cis-platin in the CH1cisR and A2780cisR acquired resistance lines.

They were also tested for possible anti-HIV activity using the HIV-I IIIB virus and C8166 cells, but they were inactive compared with AZT.