Metal-Based Drugs

Metal-Based Drugs / 1996 / Article

Open Access

Volume 3 |Article ID 487362 | https://doi.org/10.1155/MBD.1996.277

Amy L. Elkins, John G. Eley, Merrill C. Miller III, Iris H. Hall, Anup Sood, Bernard Spielvogel, "Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers", Metal-Based Drugs, vol. 3, Article ID 487362, 10 pages, 1996. https://doi.org/10.1155/MBD.1996.277

Transepithelial Transport and Metabolism of Boronated Dipeptides Across Caco-2 and HCT-8 Cell Monolayers

Received29 Dec 1996

Abstract

Oral delivery of proteins and peptides as therapeutic agents is problematic due to their low bioavailability. This study examined the effect of boronation on the transepithelial transport and metabolism of three glycine-phenylalanine dipeptides in Caco-2 and HCT-8 cell monolayers. The three dipeptides exhibited passive transport characteristics in the monolayer systems. However, metabolism of the boronated dipeptides did occur, but to a lesser extent than the non-boronated glycine-phenylalanine dipeptide. The same metabolic scheme was seen in both cell monolayer system, but greater metabolism was seen in the HCT-8 cell monolayers.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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