Table of Contents
Metal-Based Drugs
Volume 3, Issue 3, Pages 143-148

Complexes With Biologically Active Ligands. Part 61 Ni(II) Coordination Compounds of Hydrazine and Heterocyclic Sulfonamides as Inhibitors of the Zinc Enzyme Carbonic Anhydrase

1University of Valencia, Faculty of Pharmacy, Department of Inorganic Chemistry, Vincent Andres Estelles s/n, Burjassot (Valencia) E-46100, Spain
2University of Bucharest, Department of Chemistry, Bd. Carol I (Republicii) 13, Bucharest R-70346, Romania
3University of Florence, Laboratory of Inorganic and Bioinorganic Chemistry, Via Gino Capponi 7, Firenze I-50121, Italy

Received 19 April 1996; Accepted 28 April 1996

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ternary Ni(II) complexes of hydrazine and eight heterocyclic sulfonamides possessing carbonic anhydrase (CA) inhibitory properties, were prepared and characterized by elemental analysis, spectroscopic, magnetic, thermogravimetric, and conductimetric measurements. The complexes behave as strong inhibitors for two isozymes (I and II) of carbonic anhydrase.