Metal-Based Drugs

Metal-Based Drugs / 1996 / Article

Open Access

Volume 3 |Article ID 862435 | https://doi.org/10.1155/MBD.1996.63

Lorraine K. Webster, Silvina Rainone, Ernst Horn, Edward R. T. Tiekink, "Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases", Metal-Based Drugs, vol. 3, Article ID 862435, 4 pages, 1996. https://doi.org/10.1155/MBD.1996.63

Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases

Received12 Jan 1996
Accepted19 Jan 1996

Abstract

The [Ph3PAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [Ph3PAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [Ph3PAu(6-MP)] and [Ph3PAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [Ph3PAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.

Copyright © 1996 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


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