Lorraine K. Webster, Silvina Rainone, Ernst Horn, Edward R. T. Tiekink, "Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases", Metal-Based Drugs, vol. 3, Article ID 862435, 4 pages, 1996. https://doi.org/10.1155/MBD.1996.63
Anti-Tumor Activity, In Vitro and In Vivo, of Some Triphenylphosphinegold(I) Thionucleobases
The [PPAu(6-MP)] complex, where 6-MPH is 6-mercaptopurine, is active against the cisplatinresistant cell line, mouse leukaemia L1210/DDP, as is the precursor compound [PPAuCl], suggesting that the thiolate is not critical for activity. Against the human cell lines, FaDu (squamous cell carcinoma) and SKOV-3 (ovarian carcinoma), both [PPAu(6-MP)] and [PPAu(6-TG)], where 6-TGH is 6-thioguanine, were active. [PPAu(6-MP)] was active against a murine PC6 plasmacytoma, but not as active as cisplatin.
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