Table of Contents
Metal-Based Drugs
Volume 4 (1997), Issue 2, Pages 81-88
http://dx.doi.org/10.1155/MBD.1997.81

Binuclear Rhodium(II) Complexes With Selective Antibacterial Activity

1Institute of Microbiology, University of Wrocław, 63/77 Przybyszewskiego, Wrocław 51-148, Poland
2Faculty of Chemistry, University of Wrocław, 14 Joliot-Curie, Wrocław 50-383, Poland

Received 2 September 1996; Accepted 15 September 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Binuclear rhodium(II) complexes [Rh2Cl2(μ-OOCR)2(N-N)2] {R = H, Me; N-N = 2,2'-bipyridine (bpy), 1,10-phenanthroline (phen)} and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 (R = Me, Et;) have been synthesized and their structure and properties have been studied by electronic, IR and H1 NMR spectroscopy. Antibacterial activity of these complexes against Escherichia coli and Staphylococcus aureus has been investigated. The most active antibacterial agents against E. coli were [Rh2Cl2(μ-OOCR)2(N-N)2] and [Rh2(μ-OOCR)2(N-N)2(H2O)2](RCOO)2 {R = H and Me} which were considerably more active than the appropriate nitrogen ligands. The complexes show low activity against S. aureus. The activity of the complexes [Rh2(OOCR)2(N-N)2(H2O)2](OOCR)2 against E. coli decreases in the series: R=HCH3>C2H5>C3H7C4H9. The reverse order was found in the case of S. aureus.