Table of Contents
Metal-Based Drugs
Volume 4 (1997), Issue 6, Pages 317-325
http://dx.doi.org/10.1155/MBD.1997.317

Reactions of Pd(II) and Pt(II) Complexes With Tetraethylthiouram Disulfide

1Departament de Química Inorgànica, Universitat de Barcelona, Avgda Diagonal, 647, Barcelona 08028, Spain
2Institut de Ciència de Materials de Barcelona, CSIC, Bellaterra, Cerdanyola 08193, Spain

Received 11 August 1997; Accepted 19 August 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The reactions of tetraethylthiouram disulfide (DTS), an inhibitor of the nephrotoxicity of Pt(II) drugs, an efficient agent in the treatment of chronic alcoholism, in the treatment of HIV infections, AIDS and heavy metal toxicity, and a fungicide and herbicide, with K2[PtCl4], in ratio 1:1 and 1:2, gave the compounds [PtCl2DTS] and [Pt(S2CNEt2)2] respectively. The reaction of the complexes K2[PdCl4], Pd(AcO)2 and [PdCl2(PhCN)2], where PhCN = Benzonitrile, with tetraethylthiouram disulfide in ratio 1:1 or 1:2, yielded orange crystals identified as [Pd(S2CNEt2)2]. The crystals were suitable for study by X-ray diffraction. The -S-S- bridge in the tetraethylthiouram disulfude molecule was broken and the two molecules of the thiocarbamate derivative were bound to the Pd(II) by the equivalents sulfur atoms. All the compounds were characterized by IR, H1 and C13 NMR spectroscopies.