Table of Contents
Metal-Based Drugs
Volume 4 (1997), Issue 5, Pages 273-277
http://dx.doi.org/10.1155/MBD.1997.273

Considerations in Platinum and Gold Drug Design and the Synthesis of Chloro(2,3-Diphenyl-1,3,4-Thiadiazolium-5-Thiolato-Sexo)Gold(I): The First Gold Meso-Ionic Complex of Its Kind

Universidade Federal da Paraíba, Departamento de Química, CCEN, Campus I, João Pessoa CEP 58.51-970, Paraíba, Brazil

Received 8 August 1997; Accepted 8 September 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

It is evident that the chemistry of platinum is in a more advanced state than that of gold, mainly due to the success of the former in several anti-cancer drugs. With a view to finding possible, new candidates with chemotherapeutic potential, the use of sulphur-donor ligands bonded to platinum and gold is discussed herein in an attempt to promote the need to investigate similar ligands. Chloro(2,3-diphenyl-1,3,4-thiadiazolium-5-thiolato-Sexo)gold(I) has been synthesised using a standard reaction, whereby Au(III) is initially reduced to Au(I) then reacted with the ligand, 2,3-diphenyl-1,3,4-thiadiazolium-5-thiolate.hydrochloride, isolated and finally characterised by elemental analyses and infrared spectroscopy. The compound is the first example of gold attached to a meso-ionic compound. It has also been tested for anti-bacterial and anti-fungal activity and shown to possess moderate activity against Gram-positive bacteria, although is inactive against, Gram-negative bacteria and fungi.