Table of Contents
Metal-Based Drugs
Volume 4, Issue 6, Pages 305-306
http://dx.doi.org/10.1155/MBD.1997.305

Antitumor Activity of the Carboplatin-α-Cyclodextrin Adduct

1Institute of Precious Metals, Kunming 650221, China
2Kunming Medical College, Kunming 650031, China

Received 19 August 1997; Accepted 11 September 1997

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Antitumor activity of the adduct between Carboplatin and α-cyclodextrin has been tested against Sarcoma 180 (S180) and Ehrlich ascites carcinoma (EAC) murine tumors. The preliminary toxicity has also been evaluated by histological examinations of the treated animals. The results show the adduct has less antitumor efficacy than and similar toxicity to Carboplatin.