Table of Contents
Metal-Based Drugs
Volume 4, Issue 2, Pages 69-74

Biological Role of Cobalt(II), Copper(II) and Nickel(II) Metal Ions on the Antibacterial Properties of Some Nicotinoyl-Hydrazine Derived Compounds

1Department of Chemistry, Islamia University, Bahawalpur, Pakistan
2Department of Chemistry, University of Aberdeen, Meston Walk, Scotland, Old Aberdeen AB9 2UE, UK

Received 21 October 1996; Accepted 4 November 1996

Copyright © 1997 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Several cobalt(II), copper(II) and nickel(II) complexes of nicotinoylhydrazine-derived compounds were prepared and characterised by physical, spectral and analytical data. These compounds and their complexes have proven to be antibacterial. The screening data show the metal complexes to be more potential/bactericidal than the uncomplexed compounds against one or more bacterial species.