Table of Contents
Metal-Based Drugs
Volume 5, Issue 1, Pages 35-39

Synthesis, Characterization and Antitumour Activity of Metal Complexes of 5-Carboxy-2-Thiouracil

1Department of Chemistry, University of Roorkee, Roorkee 247 667, India
2Department of Chemistry, Banaras Hindu University, Varanasi 221 005, India
3School of Biotechnology, Banaras Hindu University, Varanasi 221 005, India

Received 8 August 1997; Accepted 25 August 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Metal complexes of 5-carboxy-2-thiouracil with Mn(ll), Co(ll), Ni(ll), Cu(ll), Zn(ll) and Cd(ll) ions were synthesized, characterized, and subjected to a screening system for evaluation of antitumour activity against Sarcoma-180 (S-180) tumour cells. The complexes were characterized by elemental analysis, infrared, electronic spectra, room temperature magnetic measurements and powder X-ray diffraction. The antitumour activity results indicate that some complexes have antitumour activity both in vivo and in vitro against S-180 tumour cells.