Abstract
The reactions of [2+3] cycloaddition of pyridylnitrile oxides to vinyl- and allylgermanes
proceed regioselectively and afford 5-Ge-substituted isoxazolines-2. We have synthesized 9 new
pyridyl substituted 5-Si(Ge)-isoxazolines-2 and investigated their biological activity. The
vasodilating, anticoagulant and cardioprotective activities of 5-Si(Ge) substituted isoxazolines-2
have been studied in vitro and in vivo. Substitution of the silicon atom for the germanium one
leads to the significant increase in vasodilating, antithrombotic and cardioprotective activity. The
insertion of the methylene group between Ge and the isoxazoline ring reduces the vasodilating
activity. The most active isoxazoline - 3-(