Table of Contents
Metal-Based Drugs
Volume 5, Issue 3, Pages 123-126
http://dx.doi.org/10.1155/MBD.1998.123

Potential Application of Copper Aspirinate in Preventing and Treating Thromboembolic Diseases

1Institute of Precious Metals, Kunming 650221, China
2Kunming Medical College, Kunming 650031, China

Received 12 December 1997; Accepted 6 January 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The efficacy of copper aspirinate against thrombotic diseases has been tested in animal models. The results show that copper aspirinate, following ig pretreatment for 7 days at 0.012mmol/kg markedly prolonged the bleeding time and inhibited the mortality induced by arachidonic acid (AA) in mice. On cereral ischemia model pretreatment with 0.018mmol/kg copper aspirinate ig significantly increased survival of animals and the density of intact hippocampal CA1 cells and decreased brain calcium concentration. Its anticerebral ischemia activity was superior to or equal to nimodipine. It is, therefore, suggested that copper aspirinate is very promising in becoming an antithrombotic drug in preventing and treating thrombotic diseases.