Table of Contents
Metal-Based Drugs
Volume 5 (1998), Issue 6, Pages 337-345

Ternary Copper(II) Complexes With Indomethacin, a Potent Non-Steroidal Antiinflammatory Drug. Crystal Structure of Bis (Dimethylformamide)-Tetrakis[1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-1-H-Indole-3-Acetato]Dicopper(II). Antiinflammatory Properties and Prevention of Gastrointestinal Side Effects by Nanocapsules

1CNRS URA 1534, Laboratoire de Pharmacologie, Hôspital Cochin, Paris, France
2Laboratoire de Chimie de Coordination UPR-CNRS 8241, Campus 205, Toulouse, France
3Laboratoire de Chimie Générale, Faculté de Médecine et de Pharmacie, Poitiers, France
4Laboratoire de Cristallochimie Bioinorganique, Faculté de Pharmacie Paris XI, Châtenay-Malabry, France
5Laboratoire de Biochimie, Hôspital Armand Trousseau, Paris AP-HP, France
6Laboratoire de Pharmacie Galénique, Université Claude Bernard, Lyon, France
7Laboratoire de Biochimie, Faculté des Sciences, El Jadida, Morocco
8Laboratoire de Cristallochimie Bioinorganique, Faculté de Pharmacie, 5 rue J-B Clément, Châtenay-Malabry Cedex F-92296, France

Received 19 October 1998; Accepted 16 November 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Two ternary copper(ll) complexes of indomethacin [1-(4-chlorobenzoyl)-5-methoxy-2- methyl-1-H-indole-3-acetic acid] called hereafter lndo, were prepared and characterized by single crystal X-ray diffraction. The first complex Cu2(Indo)4(DMF)2 I crystallizes in space group P-1 (a = 10.829(2), b = 13.379(2), c = 16.491(3) Å; α = 105.58(2), β = 101.06(2), γ = 106.96(2)°; V= 2104.6(6) Å3, Z= 1). The title molecule is a centrosymmetric binuclear complex, with Cu atoms bridged by the carboxylate moieties of four indomethacinate ligands. The four nearest O atoms around each Cu atom form a square planar arrangement with the square pyramidal coordination completed by the O atom of N,N′-dimethylformamide. Daily administration for seven days of 1 mg/kg of indomethacin, I and I encapsulated into liposomes induces a weak inflammation of rat gastrointestinal tract. I was less inflammatory than indomethacin but the better protection was brought by encapsulation of the compound. This might be of interest in sustained therapies of chronic inflammatory diseases.