Table of Contents
Metal-Based Drugs
Volume 5, Issue 3, Pages 139-146

Synthesis and Radioprotective Activity of New Organosilicon and Germanium Compounds

1Laboratoire d′Hétérochimie Fondamentale et Appliquée, UPRES-A 5069 du CNRS, Université Paul Sabatier, 118, route de Narbonne, Toulouse Cedex 31062, France
2Institut de Topologie et de Dynamique des Systèmes de I'Université de Paris VII, Associé au CNRS, rue Guy de la Brosse, Paris 75005, France
3Unité de Radioprotection, Centre de Recherches du Service de Santé des Armées, 24, avenue des Maquis du Grésivaudan, La Tronche Cedex 38702, France

Received 14 April 1998; Accepted 24 April 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Silathiazolidine and metalladithioacetals (M = Si, Ge) have been prepared by the interaction of dialkyldichloro- or bis(diethylamino)dialkylsilanes and -germanes with 3-[N-(2- thioethyl)]amino-propanamide (WR-2529) and [1-thioethyl-2-(1-naphtylmethyl)]-2- imidazoline. The study of these compounds in the field of chemical radioprotection has shown a notable decrease in the toxicity and a rather large increase in the radioprotective activity of these new derivatives in comparison with the starting organic compounds.