Table of Contents
Metal-Based Drugs
Volume 5, Issue 1, Pages 25-33

Six- and Seven-Membered 1-Oxa-4-Aza-2-Silacyclanes as Possible Correctors of Adaptational Mechanisms

1Russian State Medical University, Ostrovityanov St. 1, Moscow 117869, Russia
2Research Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiyskaya St. 8, Moscow 125315, Russia

Received 22 July 1997; Accepted 14 August 1997

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The biological activity of eight 1-oxa-4-aza-2-silacyclanes with the OSiCH2N fragment including 6-membered 2-sila-5-morpholinones (1–3) and 4-acyl-2-silamorpholines (4–6)and previously unknown 7-membered derivatives of salicylic acid (7, 8) was studied. Compounds 1 and 3–6 show the certain antihypoxic action. Compounds 2 (40 mg/kg), 4 (20 mg/kg), 6 (40 mg/kg), 7 (20 mg/kg) and 8 (40 mg/kg) reduce the physical serviceability of intact animals. Compound 1 (20 mg/kg) influences the physical serviceability in a moderate-positive way on the background of chlorophos-poisoning. Compounds 5–8 displayed protective properties against chlorophos-poisoning at the LD50 dose and compounds 2, 4, 5, 7 at the LD100 dose. Influence of compounds 1 and 2 on the emotional-research behavior of mice was studied.