Table of Contents
Metal-Based Drugs
Volume 5 (1998), Issue 4, Pages 245-249
http://dx.doi.org/10.1155/MBD.1998.245

Anti-Arthritic Activity in Rats of Some Phosphinegold(I) Thionucleobases and Related Thiolates

1Department of Medicine, The University of Queensland, Brisbane 4072, Queensland, Australia
2Department of Pathology, The University of Adelaide, 5005, Australia
3Department of Chemistry, The University of Adelaide, 5005, Australia

Received 8 July 1998; Accepted 14 July 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

A number of phosphinegold(I) thiolates where, generally, the thiolate is derived from a thionucleobase, have been screened for anti-arthritic activity in Dark Agouti rats, a gold sensitive model for arthritis. Potency and toxicity data showed that, generally, the Ph3P derivatives and species based on thiopurines were the most effective and that with other complexes enhanced activity was accompanied by greater toxicity.