Table of Contents
Metal-Based Drugs
Volume 5, Issue 4, Pages 207-215
http://dx.doi.org/10.1155/MBD.1998.207

Antitumour Metallocenes: Effect of DMSO on the Stability of Cp2TiX2 and Implications for Anticancer Activity

School of Chemistry, University of Sydney, 2006, N.S.W., Australia

Received 1 July 1998; Accepted 14 July 1998

Copyright © 1998 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The rate of hydrolysis of the aromatic rings of Cp2TiX2 [X = CI 1, O2CCCl38 and O2CCH2NH3Cl13], in aqueous solutions, 10%DMSO and 100% DMSO have been studied by H1NMR spectroscopy. Rapid hydrolysis of both the carboxylate and cyclopentadienyl ligands in Cp2TiX2[X = O2CCCl3,O2CCH2NH3Cl] occurs in DMSO to give biologically inactive species. The rate of these reactions are concentration dependent as dilution of these samples with saline or water to give the therapeutic conditions of 10%DMSO/90%H2O slows the hydrolysis chemistry. In contrast, samples of Cp2TiX2 [X = CI 1, O2CCH2NH3Cl13], dissolved in water give solutions containing the presumed antitumour active species in which the halide or glycine ligands have been hydrolysed but the Cp rings remain metal bound.