Metal-Based Drugs

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Volume 6 |Article ID 135471 | 4 pages | https://doi.org/10.1155/MBD.1999.149

Ferrocene-Derived Pyrazinoyl and Nicotinoyl Schiff-Bases: Their Synthesis, Characterization and Biological Properties

Zahid H. Chohan1 and M. Praveen2

1Department of Chemistry, Islamia University, Pakistan

2Department of Chemistry, Washington University, USA

Received29 Mar 1999
Accepted21 Apr 1999

Abstract

A novel class of acetylferrocene-derived Schiff-bases such as 2-pyrazinoyl-1-(2-ferroceneylmethylene)- hydrazide (HL1) and 2-nicotinoyl-1-(2-ferrocenylmethylene)hydrazide (HL2) have been synthesized and characterized by their IR, H1 NMR, C13 NMR and microanalytical date. The biological effect induced due to the coupling of ferrocene molecule with the aroylhydrazines e.g., pyrazinoylhydrazine and nicotinoylhydrazine has been studied against bacterial species such as Escherichia coli, Pseudomonas aeruginosa , Staphylococcus aureus and Klebsiella pneumonae.

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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