Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 2, Pages 121-126
http://dx.doi.org/10.1155/MBD.1999.121

Radiorecovery Activity of Dicopper(II) Tetrakis(3,5-Diiso propylsalicylate) Includes Recovery of Radiation-Induced Loss of Body Mass and Impaired Mouse Locomotion

Department of Medicinal Chemistry, College of Pharmacy, University of Arkansas for Medical Sciences Campus, Little Rock 72205, Arkansas, USA

Received 2 March 1999; Accepted 31 March 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Dicopper(II) tetrakis(3,5-diisopropylsalicylate), [Cu(II)2(3,5-DIPS)4], is effective in increasing survival of lethally irradiated mice when it is administered after irradiation. The possibility that this radiorecovery activity might also facilitate recovery from radiation-induced impaired increase in body mass and locomotion was examined. Cu(II)2(3,5-DIPS)4 was used to treat LD50/30 gamma irradiated female C57BL/6 mice after irradiation. A dose of 0, 5, 10, or 20 μmolCu(II)2(3,5-DIPS)4 /kilogram of body mass was administered subcutaneously 3 hrs after LD50/30 irradiation and change in body mass and locomotor activity measured daily throughout the 30 day post-irradiation period. Treatment with 5, 10, or 20 μmolCu(II)2(3,5-DIPS)4 /kg of body mass increased survival, which was statistically significant for the 10 μmol /kg of body mass-treated group compared to the vehicle-treated group (P<0.05) , significantly (P<0.05) increased recovery of locomotion from days 13 to 15 post-irradiation onward for all treated groups compared to vehicle-treated mice, and increased recovery of body mass gain from day 14 onward for the 20 μmol /kg of body mass-treated group (P<0.001) and day 21, although not statistically significant, for the 10 μmol /kg of body mass-treated group. There were no statistically significant differences between the increase in survival, recovered increase in body mass, and recovered increase in locomotion for mice treated with 10 μmol or 20 μmolCu(II)2(3,5-DIPS)4 /kg on day 30 post-irradiation. It is concluded that Cu(II)2(3,5-DIPS)4 in addition to increasing survival of irradiated mice increases the rate of recovery of radiation-induced decrease in body mass and locomotion.