Table of Contents
Metal-Based Drugs
Volume 6, Issue 4-5, Pages 233-238
http://dx.doi.org/10.1155/MBD.1999.233

Cyclic Voltammetry of Auranofin

Department of Chemistry, University of Maine, Orono 04469-5706, Maine, USA

Received 14 December 1998; Accepted 19 February 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The oxidative behavior of Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-β -D-glucopyranosato- S(triethylphosphine)gold(I), was investigated by using cyclic voltammetry (CV) in 0.1 M Bu4NPF6/CH2Cl2 and 0.1 M Bu4NPF4/CH2Cl2 solutions using Pt working and auxiliary electrodes and a Ag/AgCI reference. CV studies at scan rates from 50-2,000 mV/s and Auranofin concentrations between 1 and 4 mM, show two irreversible oxidation processes occurring at +1.1 V and +1.6 V vs. Ag/AgCl. Ph3PAu (p-thiocresolate) was also investigated as a reference for comparison of the oxidation processes in Auranofin to that of other phosphine gold thiolate complexes previously reported. The electrochemical response appears to be sensitive to adsorption at the electrode as well as to the nature of the supporting electrolyte solution. Repeated cycling shows a build up of products at the electrode.