Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 1, Pages 41-48
http://dx.doi.org/10.1155/MBD.1999.41

Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH2). X-Ray Crystal Structures of [Co(bdoa)(H2O)3]3.5H2O and {[CO(phen)3](bdoa)}224H2O (phen = 1,10-Phenanthroline)

1Chemistry Department, National University of Ireland Maynooth, Co. Kildare, Maynooth, Ireland
2Dublin Institute of Technology, Cathal Brugha Street, Dublin, Ireland
3School of Chemistry, Queen's University, Belfast, Ireland

Received 4 January 1999; Accepted 29 January 1999

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Co(CH3CO2)24H2O reacts with benzene-1,2-dioxyacetic acid (bdoaH2) to give the Co2+ complexes [Co(bdoa)(H2O)3]H2O (1a) and [Co(bdoa)(H2O)3]3.5H2O (1b). Subsequent reaction of 1a with 1,10- phenanthroline produces [CO(phen)3]bdoa10H2O (2a) and {[CO(phen)3](bdoa)}224H2O (2b). Molecular structures of 1b and 2b were determined crystallographically. In 1b the bdoa2- ligates the metal by two carboxylate oxygens and two ethereal oxygens, whereas in 2b the bdoa2- is uncoordinated. The Mn2+ and Cu2+ complexes [Mn(bdoa)(phen)2]H2O (3) and [Cu(pdoa)(imid)2] (4) were also synthesised, 1a-4 and other metal complexes of bdoaH2 (metal = Mn2+, Co2+ ,Cu2+, Cu+ ) were screened for their ability to inhibit the growth ofhe yeast Candida albicans. Complexes incorporating the 1,10-phenanthroline ligand were the most active.