Table of Contents
Metal-Based Drugs
Volume 6 (1999), Issue 1, Pages 25-29
http://dx.doi.org/10.1155/MBD.1999.25

Synthesis and Analgesic Activity of η6-(Anisole)- Triscarbonyl-Chromium(0)

1Universidade de Franca, Dept. of Chemistry, Avenida Dr. Armando Salles Oliveira, 201, Campus, Franca 14404-600, SP, Brazil
2Universidade de São Paulo, Faco De Filosofia, Ciências e Letras de Ribeirão Preto, Dept. of Chemistry, Campus, Ribeirão Preto 14040-901, SP, Brazil
3Universidade de São. Paulo, Fac. De Ciências Farmacêutcas de Ribeirão Preto, Campus, Ribeirão Preto 14040-903, SP, Brazil
4Universidade Federal da Paraíba, Laboratório de Tecnologia Farmacêutica, P. O Box - 5009, João Pessoa 58051-970, PB, Brazil

Received 29 June 1998; Accepted 10 July 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The general method for synthesis the η6-(arene)-triscarbonyl-chromium(0) complexes was modified and applied for preparation of η6-(anisole)-triscarbonyl-chromium(0) and the study of its analgesic activity was undertaken. A significant analgesic activity was observed after intraperitoneal injection, in Wistar rats. Two doses (30 and 50 mg/Kg of the body weight) of η6-(anisole)- triscarbonyl-chromium(0) were injected and the analgesic activity was evaluated by the Hot Plate Test method. They showed a significant analgesic effect in comparison with the control group and the group treated with dipyrone standard, but not so high when compared with the group treated with morphine standard. Overall, it was observed that the η6-(anisole)- triscarbonyl-chromium(0) was easily obtained by the modified synthetic method and was effective in increasing the pain threshold.