Table of Contents
Metal-Based Drugs
Volume 6, Issue 1, Pages 17-18

Survival and Histopathological Study of Animals Bearing Ehrlich Tumor Treated With a Rhodium(II) Amidate

1University of São Paulo, Institute of Chemistry, Av. Prof. Lineu Prestes, 748 - r. 1265, São Paulo 055508-900, Brazil
2University of São Paulo, Institute of Biomedical Sciences I, Av. Prof. Lineu Prestes, 1524, São Paulo 055508-900, Brazil
3Faculty of Medical Sciences of the Santa Casa de São Paulo, R. Da. Veridiana, 311, São Paulo 01238-010, Brazil

Received 28 September 1998; Accepted 9 October 1998

Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The survival of 90% of a tumor-bearing population treated with the complex Rh2(CF3CONH)4 was examined and the pharmacological parameter Surv90 determined. Histopathological alterations raised for this drug in several tissues were studied in Balb-c mice. A Surv90 dose of 3.8x 105 mol/kg was found.