Survival and Histopathological Study of Animals Bearing Ehrlich
Tumor Treated With a Rhodium(II) Amidate

Espósito, Breno Pannia; Zyngier, Szulim Ber; Najjar, Renato; Paes, Roberto Pinto; Ueda, Suely M. Ykko; Barros, José Carlos A.

doi:https://doi.org/10.1155/MBD.1999.17

Metal-Based Drugs

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Volume 6 | Article ID 418498 | https://doi.org/10.1155/MBD.1999.17

Survival and Histopathological Study of Animals Bearing Ehrlich Tumor Treated With a Rhodium(II) Amidate

Breno Pannia Espósito,¹Szulim Ber Zyngier,²Renato Najjar,¹Roberto Pinto Paes,³Suely M. Ykko Ueda,³and José Carlos A. Barros³

Received28 Sept 1998

Accepted09 Oct 1998

Abstract

The survival of 90% of a tumor-bearing population treated with the complex Rh2(CF3CONH)4 was examined and the pharmacological parameter Surv₉₀ determined. Histopathological alterations raised for this drug in several tissues were studied in Balb-c mice. A Surv90 dose of 3.8x 10−5 mol/kg was found.

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Copyright © 1999 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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